Can eating refrigerated biscuits left out of the fridge make you sick?

It depends on how long they have been left out. According to the USDA, refrigerated biscuits are considered safe to eat if they have been left out for no more than 2 hours at room temperature. After 2 hours, the biscuits should be discarded to avoid the risk of foodborne illness.

If you are unsure how long the biscuits have been left out, it is best to err on the side of caution and discard them. Foodborne illnesses can cause serious health problems, so it is important to take precautions to avoid them.