Can you drink grapefruit juice while on amitriptyline?

No, you should not drink grapefruit juice while taking amitriptyline. Grapefruit juice can increase the levels of amitriptyline in your blood, which can lead to side effects such as drowsiness, dizziness, confusion, and seizures. In some cases, it can even be fatal.

Amitriptyline is a tricyclic antidepressant (TCA) that is used to treat depression, anxiety, and chronic pain. It works by increasing the levels of certain neurotransmitters in the brain, such as serotonin and norepinephrine.

Grapefruit juice contains a compound called furanocoumarin, which can inhibit the CYP3A4 enzyme. This enzyme is responsible for metabolizing amitriptyline, so when it is inhibited, more amitriptyline is available to circulate in the blood.

The combination of amitriptyline and grapefruit juice can lead to a number of side effects, including:

* Drowsiness

* Dizziness

* Confusion

* Seizures

* Nausea

* Vomiting

* Diarrhea

* Headache

* Muscle pain

* Skin rash

In some cases, the combination of amitriptyline and grapefruit juice can even be fatal. If you are taking amitriptyline, it is important to avoid drinking grapefruit juice or eating grapefruit.

If you have any questions about taking amitriptyline, talk to your doctor or pharmacist.