How long do you cook a 4.5 lb pork tenderloin slow cooker?

A 4.5 lb pork tenderloin is a very large piece of meat and is not usually cooked in a slow cooker. Slow cookers are best suited for smaller cuts of meat, such as a 2-3 lb pork tenderloin. If you do decide to cook a 4.5 lb pork tenderloin in a slow cooker, you will need to cook it for 10-12 hours on low.