How long to cook brisket per pound in oven?

Brisket is a large cut of meat that comes from the breast or lower chest area of a cow. It's a flavorful, but tough cut of meat that requires long, slow cooking to tenderize. The general rule of thumb is that brisket should be cooked for 1 hour per pound in the oven at 300 degrees Fahrenheit. To ensure your brisket is cooked properly, you should insert a meat thermometer into the thickest part of the meat and cook until it reaches an internal temperature of 195-203 degrees Fahrenheit.