Can grapefruit juice irritate your bladder?

Grapefruit juice is known to interact with certain medications and affect their metabolism, but it's not commonly associated with direct bladder irritation. However, it's possible for some individuals to experience bladder irritation or discomfort after consuming large quantities of grapefruit juice. This is because grapefruit juice contains certain compounds that can act as diuretics, increasing urine output and potentially irritating the bladder. Additionally, grapefruit juice is naturally acidic, which can also contribute to bladder discomfort in some individuals. If you experience bladder irritation after consuming grapefruit juice, it may be best to limit your intake or avoid it altogether.