How much cayenne would you use to substitute for 1 tbsp of red pepper flakes?

Cayenne pepper is typically used in smaller quantities than red pepper flakes due to its intense flavor and heat. A good rule of thumb is to use about 1/4 teaspoon of cayenne pepper for every 1 tablespoon of red pepper flakes. However, it is important to taste your dish as you go and adjust the amount of cayenne pepper accordingly to your desired level of heat.