How long to cook 4.5lb bottom round roast 350?

Cooking time for a 4.5lb bottom round roast at 350°F (176°C) can vary depending on the internal temperature you prefer. Here's a general guideline for medium-rare (135°F) to medium (145°F) doneness:

Rare (130°F): Approximately 1 and a half to 2 hours

Medium Rare (135°F): Approximately 2 hours

Medium (145°F): Approximately 2 hours and 20 minutes

Medium Well (155°F): Approximately 2 hours and 40 minutes

Well Done (160°F): Approximately 3 hours

Please note that roasting times can vary based on factors such as your oven's accuracy and whether the roast is bone-in or boneless. Using a meat thermometer is the best way to ensure your roast reaches the desired internal temperature. Always allow the roast to rest for 10-15 minutes before slicing and serving.