How long to cook a 15 pound turkey at 350 degrees?

A 15-pound turkey will take approximately 4 hours and 15 minutes to cook at 350 degrees Fahrenheit. To ensure the accuracy of the cooking time, you can use a meat thermometer to check the internal temperature of the turkey. The breast should read 165 degrees Fahrenheit and the thigh should read 180 degrees Fahrenheit. Always make sure to follow food safety guidelines when cooking poultry.