Can you substitute Bisquick for cake flour?

Bisquick cannot be substituted for cake flour. Cake flour has a low protein content, which produces cakes with a fine crumb and a tender texture. Bisquick, on the other hand, has a high protein content, which produces biscuits and pancakes with a flaky texture. If you substitute Bisquick for cake flour in a cake recipe, the cake will likely be dense and gummy.