Can you have grapefruit juice if taking Atacand plus?

It is generally not recommended to consume grapefruit juice while taking Atacand Plus (candesartan cilexetil and hydrochlorothiazide), as it can potentially increase the concentration of candesartan in the body. Grapefruit juice is known to inhibit an enzyme called CYP3A4, which is responsible for the metabolism of various medications, including candesartan. By inhibiting CYP3A4, grapefruit juice can slow down the breakdown of candesartan, leading to higher levels of the drug in the body. This increased concentration of candesartan can enhance its effects and possibly increase the risk of side effects. Therefore, it is advisable to avoid consuming grapefruit juice or grapefruit-containing products while taking Atacand Plus. If you are still consuming grapefruit juice and have concerns about potential interactions, it would be best to talk with your doctor or pharmacist for personalized advice regarding your medications.