What if you take abilify with grapefruit juice?

Taking Abilify (aripiprazole) with grapefruit juice can increase the levels of Abilify in your blood, which can lead to an increased risk of side effects.

Grapefruit juice contains a compound called furanocoumarin, which inhibits the activity of CYP3A4, an enzyme responsible for metabolizing many drugs, including Abilify. By blocking the action of CYP3A4, grapefruit juice slows down the breakdown of Abilify, causing it to accumulate in the body.

This increased concentration of Abilify can potentiate its effects and increase the risk of adverse reactions such as:

- dizziness

- drowsiness

- orthostatic hypotension (sudden drop in blood pressure upon standing)

- nausea

- vomiting

- constipation

- dry mouth

- blurred vision

- confusion

- agitation

- seizures

- neuroleptic malignant syndrome (a rare but life-threatening condition characterized by high fever, muscle rigidity, altered consciousness, and autonomic dysfunction)

Therefore, it is generally recommended to avoid consuming grapefruit juice while taking Abilify. Consult your doctor or pharmacist if you have questions or concerns regarding the potential interactions between Abilify and grapefruit juice. They can provide personalized recommendations based on your medical condition and medication regimen.