Can you drink coffee with ran-pantoprazole?

Ranitidine (Zantac) and famotidine (Pepcid) are the only two histamine 2 blockers (H2BAs) that have no known interactions with caffeine. All of the PPIs (Prilosec, Prevacid, Nexium, Protonix, Aciphex, and Dexilant) significantly decrease the clearance of caffeine from the body.