Why is there numbness after eating a pufferfish meal?

Eating pufferfish can be dangerous and even fatal if the fish is not prepared correctly. The numbness you experience after eating pufferfish is caused by a neurotoxin called tetrodotoxin, which is found in the fish's liver, intestines, and gonads. Tetrodotoxin blocks the voltage-gated sodium channels in nerve cells, which prevents the transmission of electrical signals. This can lead to paralysis and respiratory failure, which can be fatal.

There is no known antidote for tetrodotoxin poisoning, so it is important to avoid eating pufferfish unless it has been prepared by a trained professional. Even then, there is still a risk of food poisoning, as tetrodotoxin can be difficult to remove completely.

If you experience any numbness or tingling after eating pufferfish, it is important to seek medical attention immediately.