Does Jose cuervo margarita mix go bad if you refrigerate after opening?

Yes, Jose Cuervo margarita mix does go bad if you refrigerate after opening. The mix will be good for about 2-3 weeks in the refrigerator, after which it will begin to lose its flavor and quality. To extend the shelf life of the mix, you can freeze it in airtight containers. The mix will be good for up to 6 months in the freezer.