Can you mix 5-htp and grapefruit juice?

Grapefruit juice contains a compound called naringin, which can inhibit the activity of certain enzymes in the body, including the enzyme that breaks down 5-HTP. This can lead to increased levels of 5-HTP in the bloodstream, which can cause side effects such as nausea, vomiting, diarrhea, and headache.

In addition, grapefruit juice can also increase the absorption of 5-HTP, which can lead to serotonin syndrome. Serotonin syndrome is a serious condition that can occur when there is too much serotonin in the body. Symptoms of serotonin syndrome can include agitation, confusion, muscle twitching, and seizures.

Therefore, it is best to avoid mixing 5-HTP and grapefruit juice. If you are taking 5-HTP, it is important to talk to your doctor about other foods and drinks that you should avoid.